In Vivo ADME Studies

Absorption, Distribution, Metabolism and Excretion (ADME) studies are a vital part of the comprehensive safety evaluation of a new chemical entity. SRI has more than 30 years of experience conducting in vivo pharmacokinetic and metabolism studies for clients in the pharmaceutical, biotechnology, and medical products industries. We are also a leader in the use of in vitro models for drug absorption and metabolism, and have excellent bioanalytical capabilities. We have biostatisticians and pharmacokineticists on-staff, applying the latest techniques and software to evaluate the data.

SRI offers extensive capabilities to conduct pharmacokinetic evaluations and analyses. These in-life studies provide information for selection of dose levels, dosing frequency, formulation, routes of administration, exposure and interspecies comparison.

• Pharmacokinetic analysis of blood (plasma)
• ADME studies in small and large animals, using radiolabelled materials, that you provide or SRI synthesizes for you
• Metabolite isolation and characterization
• Bioavailability evaluations
• Bioequivalence studies
• Formulation screening and optimization

These studies can be conducted in any laboratory species. Routes of administration include oral, intravenous, dermal, intraperitoneal, inhalation, intrathecal, and infusion as well as other intended delivery methods for your compound.

Our experience and capabilities in both in vivo and in vitro work make SRI uniquely qualified to assist you throughout the process of product development.

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     Last Updated Jul 17, 2008